The effects of FK506 and dexamethasone on rat thymocyte differentiation.
Ther Immunol
; 1(3): 135-41, 1994 Jun.
Article
em En
| MEDLINE
| ID: mdl-7584489
ABSTRACT
We investigated the effects of FK506 and glucocorticoids (GC) on rat thymocytes using flow cytofluorometry. Rats were treated with GC (0.1 mg/body, by single injection), with FK506 (1 mg/kg/day, for 7 days), or with FK506 and GC. GC alone significantly decreased the percentage of CD4+8+ thymocytes and increased the percentages of CD4-8-, CD4+8- and CD4-8+ thymocytes on day 7. FK decreased the percentage of CD4+8- and CD4-8+ thymocytes and increased the percentage of CD4+8+ thymocytes on days 5 to 14. FK and GC induced a significant decrease in the number of CD4+8+ thymocytes greater than that seen with GC alone on day 7. The absolute number of TCR alpha beta high MHC class Ihigh thymocytes after FK and GC was significantly lower than that of the control group, and was slightly lower than that after FK alone on day 14. These results suggest that combined treatment with FK506 and GC acts complexly to decrease rat CD4+8+ thymocytes and prevents thymocyte differentiation and maturation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Subpopulações de Linfócitos T
/
Tacrolimo
/
Imunossupressores
Limite:
Animals
Idioma:
En
Revista:
Ther Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão