A new aromatase inhibitor, FR901537. I. Taxonomy, fermentation, isolation, physiochemical characteristics and biological activities.
J Antibiot (Tokyo)
; 48(8): 757-62, 1995 Aug.
Article
em En
| MEDLINE
| ID: mdl-7592017
ABSTRACT
FR901537 is a new aromatase inhibitor produced by a bacterium Bacillus sp. No. 3072. Structural studies of FR901537 suggested that it was a novel naphthol derivative having pantetheine in its structure. FR901537 showed a potent inhibitory activity against aromatase from human placenta or rat ovary, but did not inhibit the activity of 11 beta-hydroxylase from bovine adrenal cortex. Lineweaver-Burk plot analysis revealed that FR901537 is a competitive inhibitor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Panteteína
/
Inibidores da Aromatase
/
Naftóis
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Japão