Muscle weakness during tricaine anesthesia.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 110(3): 289-96, 1995 Mar.
Article
em En
| MEDLINE
| ID: mdl-7599978
ABSTRACT
An isolated preparation of tadpole tail muscle was used to assess the peripheral effects of tricaine (3-aminobenzoic acid ethyl ester) at anesthetic concentrations and under physiological conditions. The drug effect on the electrically-evoked twitch was tested using short-pulse durations that elicited synaptically mediated effects or longer-duration pulses that stimulated the muscle directly. Tricaine reduced both types of response anesthetic and even subanesthetic concentrations. At steady state concentrations that produced surgical anesthesia in vivo, tricaine reduced the directly evoked response by about half. It is concluded that tricaine anesthesia has a pronounced peripheral effect on neuromuscular function and that direct effect(s) on muscle are a major component.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminobenzoatos
/
Anestésicos
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos