Immunological patterns during regular intensive training in athletes: quantification and evaluation of a preventive pharmacological approach.
J Int Med Res
; 23(2): 85-95, 1995.
Article
em En
| MEDLINE
| ID: mdl-7601298
ABSTRACT
The effects of regular intensive exercise training on immune system homeostasis and the potential value of treatment with an immunostimulating agent were assessed in this randomized, double-blind, placebo-controlled, parallel-group study. A total of 60 athletes were studied over a 3-month period of regular intensive physical activity. After 1 and 3 months there were significant decreases in the immunoglobulin levels in the whole athlete population compared with baseline values. Specifically there were significant decreases in immunoglobulin M and immunoglobulin G (G1 and G2 subclasses). There was also a significant decrease in natural killer cells and a slight but significant increase in B and T lymphocytes. In the thymomodulin-treated group, unlike the placebo group, there was no significant decrease in the immunoglobulin G2 subclass and there was a significant increase in the T-helper cell subpopulation. The clinical relevance of these immunological findings should be evaluated in larger clinical and epidemiological studies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Educação Física e Treinamento
/
Esportes
/
Extratos do Timo
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Subpopulações de Linfócitos
/
Sistema Imunitário
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Evaluation_studies
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Observational_studies
/
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
J Int Med Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Itália