Cyanopeptolin S, a sulfate-containing depsipeptide from a water bloom of Microcystis sp.
FEMS Microbiol Lett
; 129(2-3): 129-33, 1995 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-7607393
ABSTRACT
A new sulfated, cyclic depsipeptide, called cyanopeptolin S, from Microcystis sp. was isolated from a water bloom in the Auensee/Leipzig (Germany). The depsipeptide had a relative molecular mass of 925 and contained L-arginine, L-threonine, L-isoleucine, N-methyl-L-phenylalanine, a L-glutamic acid-delta-aldehyde ring system and a sulfated D-configurated glyceric acid as a side chain. The structure was elucidated by means of two-dimensional 1H and 13C nuclear magnetic resonance spectroscopy, fast atom bombardment mass spectroscopy. Fourier transformed infrared spectroscopy and combined gas-liquid chromatography/mass spectrometry. Cyanopeptolin S inhibited trypsin with an IC50 < or = 0.2 micrograms ml-1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Proteínas de Bactérias
/
Microcystis
Idioma:
En
Revista:
FEMS Microbiol Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Alemanha