Vaginal columnar cell metaplasia. An acquired adenosis associated with topical 5-fluorouracil therapy.
J Reprod Med
; 40(5): 361-6, 1995 May.
Article
em En
| MEDLINE
| ID: mdl-7608876
ABSTRACT
Vaginal adenosis, with columnar epithelium of endocervical or endometrial type forming glands within the vagina, has been observed as a congenitally acquired process, associated with in utero exposure to diethylstilbestrol; approximately 20% of those women exposed in utero have adenosis. It has been observed that vaginal adenosis may occur in nonexposed women; the origin is thought to be acquired following puberty. This study analyzed eight patients who, following topical vaginal therapy with 5-fluorouracil for vaginal intraepithelial neoplasia, had unresolving, reddened areas in the upper one-third of the vagina. Biopsy of these areas demonstrated columnar epithelium on the vaginal surface, where stratified squamous epithelium would be expected. Superficial vaginal glands (adenosis) lined with epithelium identical to the surface columnar epithelium were also identified. This finding is consistent with a metaplastic process in which stratified squamous epithelium is replaced by columnar representing columnar cell metaplasia, or acquired vaginal adenosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vagina
/
Doenças Vaginais
/
Fluoruracila
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Reprod Med
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos