Comparison of interleukin-1 alpha gene expression and protein levels in the murine spleen after lethal and sublethal total-body irradiation.
Radiat Res
; 143(3): 320-6, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-7652171
ABSTRACT
To understand the effects of ionizing radiation on the production of IL-1 alpha in vivo within a hematopoietic organ, we evaluated acute changes in splenic IL-1 alpha mRNA and IL-1 alpha protein after exposing B6D2F1 mice to lethal and sublethal 60Co radiation. Results suggest that in vivo, ionizing radiation induces a time- and dose-dependent accumulation of IL-1 alpha mRNA in the mouse spleen after exposure to gamma radiation. Time-dependent increases in the level of IL-1 alpha protein were also observed, although the magnitude of increased protein expression did not complement the magnitude of the accumulation of the message. Selective concentration of cells producing IL-1 alpha does not appear to account completely for the increase in splenic IL-1 alpha mRNA observed in this in vivo system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Baço
/
Irradiação Corporal Total
/
Interleucina-1
Limite:
Animals
Idioma:
En
Revista:
Radiat Res
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos