Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy.
FEBS Lett
; 370(3): 163-9, 1995 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-7656969
ABSTRACT
The solution structure of omega-conotoxin MVIIA (SNX-111), a peptide toxin from the fish hunting cone snail Conus magus and a high-affinity blocker of N-type calcium channels, was determined by 2D NMR spectroscopy. The backbones of the best 44 structures match with an average pairwise RMSD of 0.59 angstroms. The structures contain a short segment of triple-stranded beta-sheet involving residues 6-8, 20-21, and 24-25. The structure of this toxin is very similar to that of omega-conotoxin GVIA with which is has only 40% sequence homology, but very similar calcium channel binding affinity and selectivity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Espectroscopia de Ressonância Magnética
/
ômega-Conotoxinas
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos