Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats.
Pharmacol Biochem Behav
; 51(2-3): 415-9, 1995.
Article
em En
| MEDLINE
| ID: mdl-7667362
ABSTRACT
Rats were trained to run in a spatial, radial arm maze using a procedure to determine two memory functions, working and reference memory. The muscarinic antagonist, not the nicotinic antagonist, impaired both working and reference memory of rats. Scopolamine (0.125, 0.15, and 0.2 mg/kg, IP, 30 min before a session) significantly impaired choice accuracy in the eight-arm maze. In contrast, mecamylamine (5, 10, and 15 mg/kg) did not affect the performance. Huperzine A (0.1, 0.2, and 0.3 mg/kg, IP, 30 min before testing) and physostigmine (0.3 mg/kg, IP, 20 min before testing) could reverse scopolamine-induced deficits in the task. Chronic treatment with huperzine A (0.25 mg/kg, PO, once a day) for 8 consecutive days was as potent as acute treatment on attenuating the scopolamine-induced amnesia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Inibidores da Colinesterase
/
Aprendizagem em Labirinto
Limite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Ano de publicação:
1995
Tipo de documento:
Article