Maturational differences in coronary flow and interstitial transudate adenosine during alteration of perfusate oxygenation in isolated rabbit hearts.
Comp Biochem Physiol A Physiol
; 110(4): 367-73, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7735904
ABSTRACT
This study was designed to investigate effects of perfusate oxygenation and maturation on coronary flow (CF), interstitial transudate adenosine (ITA) and coronary effluent adenosine (CEA) in isolated rabbit hearts. Hearts were paced at a fixed rate and were perfused under constant pressure at two different levels of perfusate oxygenation baseline (B) (pO2 = 408 +/- 7 mmHg, O2 content = 1.28 +/- 0.03 ml O2/dl) and a lower level (L) (pO2 = 189 +/- 4 mmHg, O2 content = 0.59 +/- 0.02 ml O2/dl). CF was higher in immature (I, age 5 weeks) compared with mature (M, age 12 weeks) hearts at both levels of perfusate oxygenation (9.7 +/- 0.4 vs. 7.7 +/- 0.3 and 12.9 +/- 0.4 vs. 9.2 +/- 0.3 ml/min/g). I hearts had correspondingly higher values for myocardial oxygen consumption (MVO2) (53 +/- 3 vs. 49 +/- 2 and 39 +/- 3 vs. 35 +/- 2 microL O2/min/g), but similar values for venous oxygen tensions (nuO2) (240 +/- 9 vs. 219 +/- 10 and 74 +/- 4 vs. 62 +/- 3 mmHg), compared with M hearts at B and L. Although interstitial transudate adenosine (ITA) concentration was similar in I and M hearts at B (409 +/- 75 vs. 254 +/- 39 nM), it was lower in I than M hearts at L (2500 +/- 770 vs. 4210 +/- 1000 nM).(ABSTRACT TRUNCATED AT 250 WORDS)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenosina
/
Circulação Coronária
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol A Physiol
Assunto da revista:
FISIOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos