Increase in plasma TYR-MIF-1-like immunoreactivity after hypophysectomy is robust and reversible by corticosterone.
Neuropeptides
; 28(1): 65-71, 1995 Jan.
Article
em En
| MEDLINE
| ID: mdl-7746353
ABSTRACT
Tyr-MIF-1-like immunoreactivity (Tyr-MIF-1-LI) was measured in the plasma of hypophysectomized rats. The concentrations were increased in every rat examined, regardless of sex or time after hypophysectomy, and ranged from 2.5 to 10 times greater than the concentrations in intact rats. The elevated concentrations were not decreased by replacement by thyroxine, estrogen and progesterone, or acute injection of corticosterone. Chronic administration of physiological doses of corticosterone, however, did reduce the concentrations to normal. High performance liquid chromatography of tritiated Tyr-MIF-1 incubated at 37 degrees C for 3 min in plasma obtained by hypophysectomized rats eliminated the possibility that reduced degradation of Tyr-MIF-1 explained the increased concentrations. Thus, the increase in Tyr-MIF-1-LI in the plasma of hypophysectomized rats is robust and reversible by chronic replacement of corticosterone.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Corticosterona
/
Hormônio Inibidor da Liberação de MSH
Limite:
Animals
Idioma:
En
Revista:
Neuropeptides
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos