Chloroquine resistance of Plasmodium falciparum: a biological advantage?
Trans R Soc Trop Med Hyg
; 89(1): 90-1, 1995.
Article
em En
| MEDLINE
| ID: mdl-7747320
ABSTRACT
The response in vitro of Plasmodium falciparum to chloroquine, mefloquine and quinine was studied in a hyperendemic peri-urban area of Accra, Ghana, during the fourth quarter of 1991, yielding a total of 159 valid tests. Schizont maturation in drug-free controls and effective chloroquine concentrations were strongly correlated. This was not seen with mefloquine or quinine. Higher mean parasitaemia in untreated oligo-symptomatic carriers of overtly chloroquine-resistant P. falciparum than in carriers of more sensitive parasites was another indication of higher viability and biological advantage of chloroquine-resistant P. falciparum that may conceivably have clinical implications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plasmodium falciparum
/
Cloroquina
Limite:
Adolescent
/
Animals
/
Child
/
Child, preschool
/
Humans
Idioma:
En
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Áustria