Evaluation of diurnal variation in fentanyl clearance.
J Clin Pharmacol
; 35(2): 159-62, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7751426
ABSTRACT
Drug disposition kinetics are commonly assumed to be time-invariant as a first approximation. In a preliminary study, 6 healthy volunteers received a constant intravenous infusion of 50 micrograms/h for 48 hours; the serum fentanyl concentration at 36 hours was lower than that at 24 hours for all 6 subjects. This suggested possible diurnal variations in fentanyl clearance. In 2 subsequent studies, with healthy volunteers receiving short infusions of fentanyl (n = 9, 150 micrograms/h for 0.33 hours every 4 hours; n = 12, 150 micrograms/h for 0.33 hours every hour, respectively), the area under the serum fentanyl concentration curve appeared to be independent of the time of infusion. Thus, there was no evidence to support a large diurnal change in fentanyl clearance. The serum fentanyl concentration-time profiles, corrected for carryover from previous doses, within each study were superimposable. This suggests that there are no diurnal changes in the distribution kinetics of fentanyl.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fentanila
/
Ritmo Circadiano
Limite:
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos