Evidence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced tissue damage in fetal and placental tissues and changes in amniotic fluid lipid metabolites of pregnant CF1 mice.
Toxicol Lett
; 76(3): 245-50, 1995 Apr.
Article
em En
| MEDLINE
| ID: mdl-7762011
ABSTRACT
Pregnant CF1 mice were given 30 micrograms 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)/kg or the vehicle as a single i.p. dose on day 12 of gestation and killed 48 h later. Increases in DNA elution rate constants (single strand breaks) in fetal and placental nuclei of 1.8- and 2.3-fold, respectively, were observed. Increases in lipid peroxidation (thiobarbituric acid reactive substances) in placental and fetal tissues of 1.9- and 1.5-fold, respectively, were also observed. TCDD administration produced increases in the amniotic fluid levels of the lipid metabolites malondialdehyde (MDA), formaldehyde (FA), acetaldehyde (ACT), and acetone (ACON) of 2.5-, 1.6-, 1.4-, and 1.6-fold, respectively relative to control animals. The results suggest that reactive oxygen species may participate in the teratogenic effects of TCDD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Placenta
/
Feto
/
Dibenzodioxinas Policloradas
/
Líquido Amniótico
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos