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Maternal lactoferrin in the urine of preterm infants. Evidence for retention of structure and function.
Knapp, R D; Hutchens, T W.
Afiliação
  • Knapp RD; USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Adv Exp Med Biol ; 357: 177-81, 1994.
Article em En | MEDLINE | ID: mdl-7762429
Intact (i.e., 78-kDa) lactoferrin has been purified from the urine of preterm infants fed human milk. The maternal origin of this lactoferrin, and the integrity of its primary structure have been documented. Computer analyses of the circular dichroism spectra revealed a composite secondary structure for the urinary lactoferrin that was indistinguishable from that of purified human milk lactoferrin and similar to that observed in the crystal structure. Intact function was suggested by iron binding; an approximate 2:1 molar ratio of iron to lactoferrin was confirmed. Thus, maternal lactoferrin is absorbed intact by the preterm infant and appears to remain structurally and functionally intact within the circulatory system and during urinary excretion. It is possible, therefore, that maternal lactoferrin has an immunoregulatory influence in newborn infants fed human milk.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido de Baixo Peso / Recém-Nascido Prematuro / Lactoferrina / Leite Humano Limite: Female / Humans / Newborn Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recém-Nascido de Baixo Peso / Recém-Nascido Prematuro / Lactoferrina / Leite Humano Limite: Female / Humans / Newborn Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 1994 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos