[Effectiveness of isoniazid in tuberculosis chemoprophylaxis in children with rising tuberculin sensitivity]. / Effektivnost' khimioprofilaktiki tuberkuleza izoniazidom u detei s usilivaiushcheisia tuberkulinovoi chuvstvitel'nost'iu.

ABSTRACT

70 children aged 4-15 with growing tuberculin sensitivity received preventive treatment with isoniazid in children's sanatorium. The drug was taken for 2 or 3 months in a dose 10 mg/kg daily (19 and 51 children, respectively). Preventive isoniazid course proved effective as none of the children treated developed tuberculosis within 3 years. The 3-month course is preferable as it is more potent in relation to tuberculin sensitivity immediately after the treatment termination and 1, 2 years after it.