[The pharmacokinetics of the new Russian prolonged-action form of diclofenac sodium--Ortopek--in a single oral dose]. / Farmakokinektika novoi otechestvennoi prolongirovannoi formy diklofenaka natriia--ortopéka--pri odnorazovom prieme vnutr'.
Eksp Klin Farmakol
; 58(1): 53-4, 1995.
Article
em Ru
| MEDLINE
| ID: mdl-7787700
ABSTRACT
Ortopak tablets, 100 mg, were investigated. The pharmacokinetics of Ortopak was studied in 10 rheumatoid arthritis patients after a single oral dose of 100 mg. Ortophenum and voltaren-retard (Ciba-Geigy) were used for comparison. Diclophenac-sodium was measured in the patient's plasma by using high performance liquid chromatography. Ortopak was shown to be eliminated from the patient's body much slower than Ortophenum. The bioequivalence of Ortopak versus Ortophenum was 62.7%. The pharmacokinetic properties of Ortopak were similar to those of Voltaren-retard, which were close to those of diclophenac-sodium in the blood plasma within the therapeutic range.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diclofenaco
Limite:
Humans
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
1995
Tipo de documento:
Article