The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
Arch Intern Med
; 155(13): 1361-8, 1995 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-7794084
ABSTRACT
The angiotensin II (AII) type 1 receptor antagonists represent a new pharmacologic class of drugs that are specifically designed to displace AII from its type 1 receptor subtype. These drugs antagonize AII-induced biologic actions, including smooth-muscle contraction, sympathetic pressor mechanisms, and aldosterone release. Initial clinical trials suggest that these drugs are effective in the treatment of essential hypertension and hypertensive patients with intrinsic renal disease. Thus, they are the newest addition to the therapeutic armamentarium for the treatment of hypertensive diseases. We review the developmental history and pharmacology of the AII type 1 receptor antagonists. We specifically discuss the following factors mechanism(s) of action; members under clinical investigation; effects on renal function, salt and water excretion, and plasma renin activity, plasma AII type 1, and plasma aldosterone concentrations; and efficacy and safety. Given the demonstrable benefits of AII type 1 receptor blockade, these drugs should achieve broad utility in the treatment of hypertensive diseases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiofenos
/
Antagonistas de Receptores de Angiotensina
/
Anti-Hipertensivos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Intern Med
Ano de publicação:
1995
Tipo de documento:
Article
País de afiliação:
Estados Unidos