Effect of S-adenosyl-L-methionine administration on red blood cell cysteine and glutathione levels in alcoholic patients with and without liver disease.
Alcohol Alcohol
; 29(5): 597-604, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-7811344
ABSTRACT
We measured glutathione and cysteine concentrations in erythrocytes of chronic alcohol misusers with (20 subjects) and without liver cirrhosis (20 subjects). Glutathione levels were decreased, whereas those of cysteine were increased in all patients. Parenteral treatment with S-adenosylmethionine (SAME); (2 g daily in 250 ml 0.15 M NaCl for 15 days) corrected the erythrocyte thiol alterations. We conclude that parenteral treatment with SAME affects the metabolism of SH compounds in erythrocytes of alcoholic patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
S-Adenosilmetionina
/
Cisteína
/
Alcoolismo
/
Eritrócitos
/
Glutationa
/
Cirrose Hepática Alcoólica
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Alcohol Alcohol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Itália