Bacterial translocation during peroperative colonic lavage of the obstructed rat colon.
Br J Surg
; 81(12): 1796-8, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7827945
ABSTRACT
Peroperative antegrade colonic lavage is often performed before primary anastomosis in emergency colonic surgery. The influence of colonic lavage on bacterial translocation from the obstructed colon was determined. Forty female Wistar rats were studied in four groups (1) control; (2) non-obstructed with lavage; (3) obstructed; and (4) obstructed with lavage. Ligature obstruction of the rectum was performed in groups 3 and 4. Some 4 days later 35S-radiolabelled Escherichia coli was inoculated into the colon of all animals. Groups 2 and 4 underwent colonic lavage. Lavage in the group 4 animals with left-sided colonic obstruction significantly increased the levels of E. coli in regional nodes, liver, spleen, lung, kidney and blood (as assessed by organ culture and scintillation counting) compared with those in groups 1, 2 and 3 (P < 0.05). These results suggest that peroperative lavage of the obstructed colon significantly increases the level of bacterial translocation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colo
/
Doenças do Colo
/
Infecções por Escherichia coli
/
Lavagem Gástrica
/
Obstrução Intestinal
Limite:
Animals
Idioma:
En
Revista:
Br J Surg
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Irlanda