Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia.
Eur Arch Otorhinolaryngol
; 251(6): 325-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7848641
ABSTRACT
Decreased mucociliary transport can occur in patients with type I (IgE-mediated) allergic rhinitis or allergic asthma. This study investigated if the allergic mediators histamine and leukotriene C4 (LTC4) could interfere with ciliary beat frequency (CBF) of in vitro human upper respiratory cilia and eventually result in decreased mucociliary transport. Ciliated epithelium of human adenoid tissue was used in the experiments and CBF was determined using a computer-assisted photoelectric method. Histamine in concentrations of 10(-6) - 10(-3) M (n = 12) and LTC4 as 10(-9) - 10(-6) M solutions (n = 10) showed no statistically significant dose-dependent effect on CBF in vitro.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tonsila Faríngea
/
Histamina
/
Depuração Mucociliar
/
Leucotrieno C4
Limite:
Child
/
Humans
Idioma:
En
Revista:
Eur Arch Otorhinolaryngol
Assunto da revista:
OTORRINOLARINGOLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Holanda