Correlation between [125I]calmodulin binding and lipid fluidity in synaptic plasma membranes: effects of ethanol and other short-chain alcohols.
Brain Res Mol Brain Res
; 27(2): 333-6, 1994 Dec.
Article
em En
| MEDLINE
| ID: mdl-7898320
ABSTRACT
Ethanol inhibits [125I]calmodulin binding to synaptic plasma membranes from rat brain, and this inhibition is correlated in a concentration-dependent manner with the increase of membrane fluidity, as determined by diphenylhexatriene fluorescence polarization. Moreover, several short-chain alcohols that increase membrane fluidity are also effective inhibitors of [125I]calmodulin binding. These data support the notion that ethanol inhibits calmodulin binding by increasing lipid fluidity of the synaptic membranes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membranas Sinápticas
/
Calmodulina
/
Etanol
/
Metabolismo dos Lipídeos
Limite:
Animals
Idioma:
En
Revista:
Brain Res Mol Brain Res
Assunto da revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Ano de publicação:
1994
Tipo de documento:
Article