Activation of multiple transcription factor genes by tetrahydrocannabinol in rat forebrain.
Neuroreport
; 5(10): 1265-8, 1994 Jun 02.
Article
em En
| MEDLINE
| ID: mdl-7919180
ABSTRACT
delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We have recently localized a receptor for THC in the forebrain and found in the caudate-putamen that its gene expression is modulated by glucocorticoids, dopamine and glutamate. Here, we report for the first time, using quantitative in situ hybridization, that acute THC (5 mg kg-1, i.p.) regulates the mRNA levels of multiple immediate early genes in the adult rat forebrain. Twenty minutes after a single THC injection, significant increases in concentration of the mRNAs for C-FOS, C-JUN and ZIF-268 were observed in the cingulate cortex (75, 45 and 37%) and for C-FOS and ZIF-268 in the fronto-parietal cortex (60 and 64%) and caudate-putamen (81 and 32%) while JUN-D mRNA levels were not changed. These transcription factor genes might mediate putative THC modulation of neurotransmitter gene expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dronabinol
/
Expressão Gênica
/
Prosencéfalo
/
Genes Precoces
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Bélgica