Fate of wheat bound malathion residues in rats during gestation.
Chemosphere
; 29(3): 451-5, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7922151
ABSTRACT
Malathion [S-1,2-di(ethoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate], treated wheat when stored for 28 months at 20 degrees C with or without food grade white mineral oil on grains contained about 62 and 79% of the applied insecticide as bound residues, respectively. These bound residues were present mainly in the form of the parent compound. The stored wheat containing bound malathion residues, as well as wheat material freshly spiked with malathion were fed to rats during gestation. No residues of malathion and/or metabolites were detected in urine, feces and body tissues. Further no significant effect on body weight, serum chemistry and cytochrome P450 levels were observed in the mothers. There was no evidence for the histopathological alteration or teratogenic anomalies in the fetuses. However, placental transfer of malathion was indicated by the presence of the insecticide residues in fetuses from rats fed wheat material containing bound residues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resíduos de Praguicidas
/
Feto
/
Malation
/
Troca Materno-Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Chemosphere
Ano de publicação:
1994
Tipo de documento:
Article