Synthesis of doxorubicin-cyclodextrin conjugates.
J Antibiot (Tokyo)
; 47(9): 1025-9, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-7928690
ABSTRACT
Doxorubicin-gamma-cyclodextrin conjugates have been synthesized by the coupling of 14-bromodaunomycin with mono half-ester compounds linked to a 6-hydroxyl group of gamma-cyclodextrin. Release of drug from the conjugates in saline phosphate buffer solution and in vitro antitumor activity against L1210 leukemia cells were also investigated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doxorrubicina
/
Ciclodextrinas
Limite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Japão