[G-proteins coupled receptors]. / Les récepteurs couplés aux protéines G.
Rev Prat
; 44(9): 1163-7, 1994 May 01.
Article
em Fr
| MEDLINE
| ID: mdl-7939337
ABSTRACT
The superfamily of G protein-coupled receptors plays a major role in the transmission and amplification of extracellular stimuli. These membrane receptors have a common structure made of a single polypeptide chain including seven transmembrane spanning domains. The comparison of amino acid sequences of the various G protein-coupled receptors reveals several conserved amino acids and regions playing a key role in ligand binding, G protein coupling, and activation of intracellular second messengers. Mutations of amino acid sequences of seven transmembrane domain receptors and their coupled G proteins are responsible for various human diseases including certain kinds of cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Superfície Celular
/
Proteínas de Ligação ao GTP
Limite:
Humans
Idioma:
Fr
Revista:
Rev Prat
Ano de publicação:
1994
Tipo de documento:
Article