[Study on mitoxantrone polycyanoacrylate nanospheres].
Yao Xue Xue Bao
; 29(7): 544-9, 1994.
Article
em Zh
| MEDLINE
| ID: mdl-7976360
ABSTRACT
The mitoxantrone polybutylcyanoacrylate nanosparticles (DHAQ-PBCA-NP) were prepared by emulsion polymerization method. The surface charge, drug loading, morphology, size and size distribution, release characteristics in vitro, stability and distribution in animals of DHAQ-PBCA-NP were studied. The results showed that the mean size was d(av) = 55.23 nm, drug loading was 46.77%, embedding ratio was 84.89%. The surface carried negative charge and the release characteristics in vitro was in accord with two phases kinetics law. The colloidal solution of DHAQ-PBCA-NP can undergo boiling for 30 min sterilization. The radioactivity concentrated mainly in liver after iv 3H-DHAQ-PBCA-NP. The radioactivity in liver tumor was higher than that in the liver tissue. DHAQ-PBCA-NP was observed in parenchymal cell 15 min after iv DHAQ-PBCA-NS. This preparation seems to have important value for increasing the anti-liver tumor effect and decreasing the toxicity of DHAQ.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Mitoxantrona
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
1994
Tipo de documento:
Article