Lysis of blood platelets by human osteosarcoma cells in vitro.
Blood Cells
; 20(1): 203-16; discussion 217-8, 1994.
Article
em En
| MEDLINE
| ID: mdl-7994061
ABSTRACT
The in vitro interactions between human osteosarcoma (HOS) cells and platelets were studied in real time using video-enhanced microscopy. Interference reflection techniques showed that platelets were lysed within minutes after contacting HOS cells that had been treated with interferon-gamma. Untreated HOS cells lysed platelets less efficiently. Platelet lysis depended on platelet-tumor cell contact and on extracellular Ca2+. A number of possible mechanisms were excluded. Lysis of platelets in proximity to tumor cells can provide these with growth factors and thereby contribute to the metastasis-enhancing effect of platelets.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Osteossarcoma
/
Hemólise
Limite:
Humans
Idioma:
En
Revista:
Blood Cells
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Suíça