Cell cycle control and cancer.
Science
; 266(5192): 1821-8, 1994 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-7997877
ABSTRACT
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ciclo Celular
/
Transformação Celular Neoplásica
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1994
Tipo de documento:
Article