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Cell-type-specific induction of the UL9 gene of HSV-1 by cell signaling pathway.
Deb, S P; Deb, S; Brown, D R.
Afiliação
  • Deb SP; Department of Microbiology, University of Texas Health Science Center at San Antonio, 78284-7758.
Biochem Biophys Res Commun ; 205(1): 44-51, 1994 Nov 30.
Article em En | MEDLINE | ID: mdl-7999061
The origin-binding protein, encoded by the UL9 gene of herpes simplex virus-1 (HSV-1), has the properties of an initiator of DNA replication. In this communication, we report that the UL9 promoter contains a cAMP-response element (CRE). Transient expression analyses show that dibutyryl cyclic AMP, known to elevate intracellular cAMP level, can induce the UL9 promoter in a rat pheochromocytoma cell line (PC12) but not in a non-neuronal human cell line (HeLa). Interestingly, a transcription factor that increases expression of a neuropeptide gene by interacting with CRE can also activate the UL9 promoter independent of cell type. Thus, our data suggest that extracellular stimuli, capable of interacting with the signaling pathway in neuronal cells, can activate UL9 gene expression, and different proteins may regulate UL9 expression in different cell types.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Transdução de Sinais / Herpesvirus Humano 1 / DNA Helicases / Proteínas de Ligação a DNA Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 1994 Tipo de documento: Article País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Virais / Transdução de Sinais / Herpesvirus Humano 1 / DNA Helicases / Proteínas de Ligação a DNA Limite: Animals / Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 1994 Tipo de documento: Article País de publicação: Estados Unidos