An eye-specific G beta subunit essential for termination of the phototransduction cascade.
Nature
; 370(6484): 59-61, 1994 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-8015606
ABSTRACT
Heterotrimeric G proteins couple various receptors to intracellular effector molecules. Although the role of the G alpha subunit in effector activation, guanine nucleotide exchange and GTP hydrolysis has been well studied, the cellular functions of the G beta subunits are less well understood. G beta gamma dimers bind G alpha subunits and anchor them to the membrane for presentation to the receptor. In specific systems, the G beta subunits have also been implicated in direct coupling to ion channels and to effector molecules. We have isolated Drosophila melanogaster mutants defective in an eye-specific G-protein beta-subunit (G beta e), and show here that the beta-subunit is essential for G-protein-receptor coupling in vivo. Remarkably, G beta mutants are also severely defective in the deactivation of the light response, demonstrating an essential role for the G beta subunit in terminating the active state of this signalling cascade.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Fotorreceptoras de Invertebrados
/
Proteínas de Ligação ao GTP
/
Olho
/
Condução Nervosa
Limite:
Animals
Idioma:
En
Revista:
Nature
Ano de publicação:
1994
Tipo de documento:
Article