Isolation of an adhesin from Staphylococcus aureus that binds Lewis a blood group antigen and its relevance to sudden infant death syndrome.
FEMS Immunol Med Microbiol
; 8(4): 315-20, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-8061655
ABSTRACT
A 67 kDa protein was isolated from cell membrane preparations of Staphylococcus aureus (NCTC 10655) by affinity adsorption with synthetic Lewis a antigen conjugated to Synsorb beads. Pre-treatment of buccal epithelial cells expressing Lewis a with the purified protein reduced binding of the staphylococcal strain to a greater extent than the material not bound to the Synsorb beads. The significance of this work is discussed with reference to expression of Lewis a antigen in infants and the proposed role of toxigenic strains of staphylococci in some cases of sudden infant death syndrome.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Aderência Bacteriana
/
Adesinas Bacterianas
/
Antígenos do Grupo Sanguíneo de Lewis
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Infant
Idioma:
En
Revista:
FEMS Immunol Med Microbiol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido