A specific inhibitor of the epidermal growth factor receptor tyrosine kinase.
Science
; 265(5175): 1093-5, 1994 Aug 19.
Article
em En
| MEDLINE
| ID: mdl-8066447
ABSTRACT
A small molecule called PD 153035 inhibited the epidermal growth factor (EGF) receptor tyrosine kinase with a 5-pM inhibition constant. The inhibitor was specific for the EGF receptor tyrosine kinase and inhibited other purified tyrosine kinases only at micromolar or higher concentrations. PD 153035 rapidly suppressed autophosphorylation of the EGF receptor at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells and selectively blocked EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. PD 153035 demonstrates an increase in potency over that of other tyrosine kinase inhibitors of four to five orders of magnitude for inhibition of isolated EGF receptor tyrosine kinase and three to four orders of magnitude for inhibition of cellular phosphorylation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Receptores ErbB
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1994
Tipo de documento:
Article