Some noradrenergic neurons of locus ceruleus-olfactory pathways contain neuropeptide-Y.
Brain Res Bull
; 34(4): 413-7, 1994.
Article
em En
| MEDLINE
| ID: mdl-8082034
ABSTRACT
We report a specific tracing technique for studying projections of noradrenergic neurons that contain other transmitters. Autoradiography after retrograde axonal transport of tritiated-noradrenaline ([3H]NA) was combined with immunocytochemical detection of endogenous NA or neuropeptide Y (NPY). The specificity of [3H]NA retrograde labeling was dependent on the concentration of [3H]NA injected at the terminal region. At 2 x 10(-3) M, the specificity of [3H]NA retrograde labeling was confirmed by immunodetection of endogenous NA in radiolabeled cell bodies of the locus ceruleus. Combination of autoradiography of [3H]NA retrograde labeling with immunodetection of NPY demonstrated that a some scattered locus ceruleus noradrenergic neurons (about 26%) projecting to the olfactory bulb do contain NPY.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condutos Olfatórios
/
Neuropeptídeo Y
/
Locus Cerúleo
/
Norepinefrina
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Brain Res Bull
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
França