[Measurement and fluctuation of urinary glucaric acid in pregnant women].
Nihon Sanka Fujinka Gakkai Zasshi
; 46(7): 567-72, 1994 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-8089594
ABSTRACT
It is known that urinary excretion of glucaric acid (GA) is an indirect index of hepatic P-450 microenzyme induction. We measured and analyzed urinary excretion of GA and plasma lipids in non-pregnant women, pregnant women and postpartum women. GA was measured by a new method for the inhibition of beta-glucuronidase activity and plasma lipids were measured by routine laboratory methods and we obtained the following results. 1. The concentration of urinary GA was correlated with that of urinary creatinine in pregnant women. 2. The urinary GA and plasma HDL-cholesterol did not change during the first of gestation, but steeply increased in the middle of gestation, and postpartum values were lower than at term. 3. Plasma total lipids, triglycerides, and total cholesterol continuously increased throughout gestation. 4. Plasma free fatty acids and lipid peroxide steeply increased in late in gestation. These results and several reports suggested that the change in GA in pregnant women reflected their own metabolism not fetal or placental metabolism. It seems that grasping and understanding their metabolism can make their disease clear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez
/
Ácido Glucárico
Limite:
Female
/
Humans
Idioma:
Ja
Revista:
Nihon Sanka Fujinka Gakkai Zasshi
Ano de publicação:
1994
Tipo de documento:
Article