Lethality and mutagenesis of B lymphocyte progenitor cells following exposure to alpha-particles and X-rays.
Int J Radiat Biol
; 66(2): 197-205, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-8089629
ABSTRACT
B lymphocyte precursor cells are the target cells for the major subtype of paediatric cancer, acute lymphoblastic leukaemia. Using a murine IL-7-dependent clonogenic assay for normal B cell precursors as a model, we have investigated the sensitivity of these cells versus other normal and leukaemic haemopoietic cells to alpha-particle radiation. We find that B cell precursors are remarkably susceptible to the lethal effects of alpha-particles and have a very low probability of surviving a single alpha-track. B cell precursors are also very sensitive to the lethal effects of low LET X-rays. The mutation frequency in a marker gene (HPRT) does not, however, appear to be greater in B cell precursors that survive X-radiation than in other haemopoietic cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Raios X
/
Células-Tronco Hematopoéticas
/
Linfócitos B
/
Mutagênese
/
Partículas alfa
Limite:
Animals
Idioma:
En
Revista:
Int J Radiat Biol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido