Tosyl arginine methyl ester induces bronchoconstriction in rabbit bronchial tissues in vitro: a possible new mediator in asthma.
Ann Allergy
; 73(3): 269-70, 1994 Sep.
Article
em En
| MEDLINE
| ID: mdl-8092563
ABSTRACT
Tosyl arginine methyl ester induced bronchoconstriction in rabbit bronchial rings mounted in vitro with a calculated EC50 of 5.6 x 10(-5) M as compared with acetylcholine which induced sustainable constriction with an EC50 of 2.5 x 10(-6) M. Tosyl arginine methyl ester, however, had definite bronchoconstricting properties though less potent than acetylcholine. We concluded that our data support the hypothesis that tosyl arginine methyl ester could be a possible biochemical mediator of airway contraction.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Tosilarginina Metil Éster
/
Brônquios
/
Broncoconstrição
Limite:
Animals
Idioma:
En
Revista:
Ann Allergy
Ano de publicação:
1994
Tipo de documento:
Article