Do the hydrolysis products, methylamine and N,N'-dimethylurea, play any role in the methyl isocyanate-induced haematological and biochemical changes in rabbits?
Hum Exp Toxicol
; 12(2): 135-9, 1993 Mar.
Article
em En
| MEDLINE
| ID: mdl-8096711
ABSTRACT
The subcutaneous administration of methyl isocyanate (MIC) to female rabbits, resulted in significant increases in haemoglobin concentration, erythrocyte volume fraction and leucocyte number in blood, as well as plasma total proteins, and urea. The present study was designed to investigate whether the hydrolytic products of MIC, methylamine (MA) and N,N'-dimethylurea (DMU) play any role in eliciting these changes. Both MA and DMU administered subcutaneously in an equimolar dose to that of 1.0 LD50 MIC, 2.2 mmol kg-1, had no influence on these parameters, although there was a marginal increase in the plasma urea level shortly after the administration of DMU. This study establishes that the observed haematological and biochemical changes induced by MIC intoxication in rabbits are mostly due to MIC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isocianatos
/
Cianatos
/
Hemorragia
/
Metilaminas
/
Compostos de Metilureia
/
Antidrepanocíticos
Limite:
Animals
Idioma:
En
Revista:
Hum Exp Toxicol
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Índia