Cause of death in multiple endocrine neoplasia type 1.
Arch Surg
; 128(6): 683-90, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8099273
ABSTRACT
OBJECTIVE:
Little data are available on the natural history of untreated multiple endocrine neoplasia type 1 (MEN-1). These data are essential in deciding treatment that may carry significant morbidity. We determined the causes of death in a large MEN-1 kindred with data available over a period of 130 years. Most cases were unrecognized as MEN-1 at the time of patient's death.DESIGN:
Retrospective study of recorded medical data from 1861 to 1991. PATIENTS One hundred fifty-nine deaths occurred, of which 46 were in individuals classified as "highly probable" of having MEN-1.RESULTS:
Of 46 deaths in those classified as "highly probable" of having MEN-1, 20 (43.5%) died of a recognized complication of MEN-1 (12 of malignant neoplasms, six of renal calculi, and two of peptic ulcer). If accidental deaths are excluded, 50% of the deaths in patients with MEN-1 were the result of MEN-1, and the mean age of death (50.9 years)was significantly younger than that of other family members.CONCLUSIONS:
It is concluded that MEN-1 leads to premature death, and that neoplasia rather than peptic ulcer disease is the main cause of death. Deaths from pituitary tumor or malignant endocrine tumors within the thorax were just as common or more common than deaths from pancreatic malignant neoplasms.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasia Endócrina Múltipla
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Oceania
Idioma:
En
Revista:
Arch Surg
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Austrália