Characterization and chemosensitivity of a human epithelioid sarcoma cell line (SARCCR 2).
Int J Cancer
; 54(4): 663-8, 1993 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-8099901
ABSTRACT
A new cell line was derived from the epithelioid sarcoma of a Caucasian woman who had previously received chemotherapy. The cells grew as an adherent monolayer, with a doubling time of 28 hr and had mainly epithelial morphology, but with areas of mesenchymal-like cytoplasmic extensions. The cells were tumorigenic in nude mice, with a short growth time, and a doubling time of 8 days. The cell line showed over-expression of P-glycoprotein by Western blot analysis, and its sensitivity to doxorubicin and vincristine was low. This sensitivity could be enhanced by reversants of multidrug resistance (MDR), such as cyclosporin or verapamil. This cell line constitutes an excellent model for studying compounds able to reverse MDR.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
Limite:
Adult
/
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
França