Localized lepromatous leprosy and its response to chemo-immunotherapy.
Int J Dermatol
; 33(1): 64-7, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8112948
ABSTRACT
BACKGROUND:
This is an unusual presentation of lepromatous leprosy (LL) in a young boy, 12 years of age. The study forms part of a large scale immunotherapeutic trial with Mycobacterium w (M.w) antileprosy vaccine. The trial is being conducted in two major hospitals in New Delhi, India. MATERIALS ANDMETHODS:
This patient presented with three lesions one on each forearm and the third on the left leg. He was classified initially as borderline tuberculoid leprosy. Slit-skin smears and histopathology from the lesions proved the diagnosis to be lepromatous leprosy with a bacterial index (BI) 6+. The initial lepromin test was negative. The patient was treated with chemo-immunotherapy (standard multidrug therapy and immunotherapy with Mycobacterium w vaccine).RESULTS:
Investigations after 1 year (15 months) of multi-drug therapy and three doses of vaccine, showed a remarkable fall in the BI from 6 to 0 in the lesions, a lepromin positivity of 5 mm, and a histological upgrading from lepromatous leprosy to borderline tuberculoid. Immunologic studies at 15 months revealed a good LTT response and high levels of cytokines, specifically IL-2 and IFN-gamma.CONCLUSIONS:
This report presents an LL patient with disease limited to a few sites. It stresses the importance of slit-smear and biopsy in all patients of leprosy, and it highlights the upgrading observed on administration of chemo-immunotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Hanseníase Virchowiana
/
Hansenostáticos
Limite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
Int J Dermatol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Índia