[Role of phosphorylcholine group on inhibiting capacity of lecithin-cholesterol liposomes on streptolysin O]. / Rôle du groupement phosphorylcholine sur le pouvoir inhibiteur des liposomes lécithines-cholestérol vis-à-vis de la streptolysine O
C R Acad Hebd Seances Acad Sci D
; 280(9): 1165-8, 1975 Mar 03.
Article
em Fr
| MEDLINE
| ID: mdl-811390
ABSTRACT
Cholesterol inhibition of the hemolytic activity of streptolysin O was used for testing the presence of cholesterol on the surface of lecithin-cholesterol liposomes. Cholesterol as a liposome component is not available for streptolysin inhibition when the molar ratio lecithin-cholesterol greater than 1,25. Incubation of such liposomes with phospholipase C, which converts the phosphadylcholine group into neutral diglycerides, restores an inhibiting activity of cholesterol parallel to the phosphatid degradation. Incubation of the liposomes with phospholipase D, which converts the phosphatidylcholine group into phosphatidic acid, also restores the inhibiting capacity of cholesterol on the hemolysin. The accessibility of liposome cholesterol to streptolysin O appears to mainly depend upon the cholin group of lecithin.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosforilcolina
/
Estreptolisinas
/
Colesterol
/
Colina
Idioma:
Fr
Revista:
C R Acad Hebd Seances Acad Sci D
Ano de publicação:
1975
Tipo de documento:
Article