Adrenalectomy but not adrenal demedullation during pregnancy prevents the growth-retarding effects of fetal alcohol exposure.
Alcohol Clin Exp Res
; 17(6): 1281-9, 1993 Dec.
Article
em En
| MEDLINE
| ID: mdl-8116843
ABSTRACT
Growth retardation, both in the prenatal and the early neonatal period, is a consistent feature of fetal alcohol exposure, but the mechanism by which alcohol affects growth has not been elucidated. Because other stressors--such as maternal restraint and neonatal glucocorticoid treatment--can also affect growth, we examined the effect of ethanol on pup birthweight under two experimental conditions that altered maternal adrenal function. In the first study when dams were adrenalectomized and given low replacement doses of dexamethasone, the ethanol-exposed offspring of the adrenalectomized dams had birthweights similar to those of dams maintained on regular lab chow diets. In a second study, we found that maternal adrenal demedullation did not alter the reduction in birthweight produced by fetal ethanol exposure. The results suggest that the effects of ethanol on fetal growth may be mediated in part through ethanol-induced changes in the function of the maternal adrenal cortex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Suprarrenal
/
Medula Suprarrenal
/
Transtornos do Espectro Alcoólico Fetal
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Alcohol Clin Exp Res
Ano de publicação:
1993
Tipo de documento:
Article