Sneddon's syndrome, anti-cardiolipin antibody and glomerular thrombosis.
Clin Nephrol
; 41(1): 18-22, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8137565
ABSTRACT
Sneddon's syndrome, cerebrovascular thrombosis and livedo reticularis, is often a variant of the "primary" anti-phospholipid syndrome (PAPS). We report a woman with PAPS, presenting as Sneddon's syndrome, with renal impairment and glomerular thrombosis on renal biopsy. An IgG anti-cardiolipin antibody (aCL) was identified. The aCL was purified by affinity chromatography, gel filtration chromatography and ion-exchange chromatography, assayed in a modified ELISA and found to be of the type that requires the plasma protein beta 2-GPI to bind aCL. As beta 2-GPI has anticoagulant properties it is postulated that its interaction with aCL has a pathogenic role in the thrombotic lesions associated with aCL.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trombose
/
Embolia e Trombose Intracraniana
/
Dermatopatias Vasculares
/
Anticorpos Anticardiolipina
/
Nefropatias
/
Glomérulos Renais
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Clin Nephrol
Ano de publicação:
1994
Tipo de documento:
Article