The inhibitory effects of topical chelating agents and antioxidants on nickel-induced hypersensitivity reactions.
J Am Acad Dermatol
; 30(4): 560-5, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-8157781
ABSTRACT
BACKGROUND:
Nickel sensitivity is a common problem, often causing significant morbidity from chronic eczematous dermatitis. The main treatment, topical steroids, usually is unable to suppress the dermatitis completely.OBJECTIVE:
Our purpose was to study the effects of "barrier" ointments containing either chelating agents (clioquinol or ethylenediaminetetraacetic acid [EDTA]) or antioxidants (ascorbic acid or alpha-tocopherol) and 1% hydrocortisone on nickel-induced hypersensitivity reactions.METHODS:
Nickel-sensitive subjects were challenged with nickel-containing coins coated with the desired barrier ointment and their inhibitory effects observed. Patients with bilateral hand or earring dermatitis explored the efficacy of these agents in clinical use.RESULTS:
Clioquinol (3%) completely abolished the allergic reaction in all 29 subjects tested. EDTA (15%), ascorbic acid (20%), and alpha-tocopherol (10%) were less effective, and 1% hydrocortisone had no significant effect. In clinical use sites treated with a commercially available preparation containing 3% clioquinol and 1% hydrocortisone showed marked clinical improvement in all 10 subjects.CONCLUSION:
Clioquinol is a potent inhibitor of nickel-induced hypersensitivity reactions and is feasible to use as a barrier ointment to block the allergenic effects of nickel in sensitive patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Quelantes
/
Dermatite Alérgica de Contato
/
Toxidermias
/
Níquel
/
Antioxidantes
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido