Familial giant cell arteritis: report of an HLA-typed sibling pair and a review of the literature.
Clin Exp Rheumatol
; 12(1): 63-6, 1994.
Article
em En
| MEDLINE
| ID: mdl-8162645
ABSTRACT
We report a brother and sister who developed biopsy-proven giant cell arteritis four years apart and summarize the eight previously well-documented families of first-degree relatives with unequivocal disease. HLA haplotypes for both siblings included DRB1*03 (DR3) and the *0401 allele of DRB1*04 (DR4). The reported association of giant cell arteritis with HLA-DR4 and its occurrence in first-degree relatives support a genetic component in its pathogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arterite de Células Gigantes
/
Antígenos HLA
Limite:
Aged
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Female
/
Humans
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Male
Idioma:
En
Revista:
Clin Exp Rheumatol
Ano de publicação:
1994
Tipo de documento:
Article