Metabolic correlates of theophylline therapy: a concentration-related phenomenon.
Ann Pharmacother
; 28(2): 175-9, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8173127
ABSTRACT
OBJECTIVE:
To determine the relationship of serum theophylline concentration with electrolyte and glucose abnormalities across a broad range of theophylline concentrations.DESIGN:
Retrospective review of a computerized laboratory database between June 1, 1984 and June 1, 1986.SETTING:
A midwestern university medical center. PATIENTS Eight hundred sixty-nine patients with serum theophylline concentrations of > 5.5 mumol/L and a random unmatched sample (control group) of 350 in- and outpatient adults and children with no history of reactive airways disease or theophylline exposure.RESULTS:
Patients with measurable theophylline had a higher risk of hypokalemia, hyponatremia, hyperglycemia, hypophosphatemia, and hypomagnesemia compared with the unexposed control group. Unadjusted odds ratios (OR) were (1) hypokalemia OR = 4.2 (95 percent CI 2.2 to 7.9); (2) hyponatremia OR = 5.4 (95 percent CI 2.0 to 12.9); (3) hypomagnesemia OR = 1.6 (95 percent CI 1.0 to 2.5); (4) hyperglycemia OR = 2.3 (95 percent CI 1.7 to 3.0); and (5) hypophosphatemia OR = 2.7 (95 percent CI 1.2 to 5.3). A linear concentration-response relationship was documented between serum theophylline concentration and all metabolic disturbances.CONCLUSIONS:
Measurable theophylline was associated with increased risk for glucose and electrolyte abnormalities in a concentration-related fashion across a broad range of theophylline concentrations from 5.5 to > or = 110 mumol/L.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Teofilina
/
Doenças Metabólicas
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Ann Pharmacother
Assunto da revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
1994
Tipo de documento:
Article