Hepatitis B viral clearance studies using duck virus model.
Dev Biol Stand
; 81: 163-8, 1993.
Article
em En
| MEDLINE
| ID: mdl-8174798
ABSTRACT
We have shown data to suggest that the in vivo duck hepatitis B virus system represents an excellent animal model system for the study of hepatitis B virus. Because of the similarity of DHBV to human HBV (including comparable results in virus inactivation studies), the high level of sensitivity of the DHBV assay, and the rapidity, ease, and relative low cost of obtaining results, we propose that the in vivo DHBV titration system be used as a model for human HBV in process validation studies. Data generated in such validation studies have, in fact, been submitted by a number of blood products manufacturers to the U.S. F.D.A. in support of IND applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Viremia
/
Virologia
/
Bioensaio
/
Vírus da Hepatite B do Pato
/
Vírus da Hepatite B
/
Modelos Animais de Doenças
/
Patos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Biol Stand
Ano de publicação:
1993
Tipo de documento:
Article