Posttransplant skin cancer: a possible role for p53 gene mutation but not for oncogenic human papillomaviruses.
J Am Acad Dermatol
; 30(5 Pt 1): 701-6, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-8176007
ABSTRACT
BACKGROUND:
Loss of p53 tumor suppressor function is a critical step in the development of diverse malignancies, including skin cancers in nonimmunosuppressed patients where UV-specific p53 gene mutations have been identified. In tumors associated with human papillomavirus (HPV), such as cervical carcinoma, p53 may be inactivated instead by binding to a viral oncoprotein.OBJECTIVE:
Our purpose was to examine the hypothesis that HPV may play an analogous role in the development of posttransplant skin cancer.METHODS:
p53 Immunoreactivity, suggestive of p53 gene mutation, was examined by immunocytochemistry. Oncogenic HPV DNA was detected by polymerase chain reaction.RESULTS:
Comparable p53 immunoreactivity was seen in skin tumors from both transplant and nontransplant patients. HPV DNA was not demonstrated in any tumor specimen.CONCLUSION:
Our data do not implicate oncogenic HPV in posttransplant skin cancer. p53 Gene mutation, rather than HPV-induced p53 degradation, may be more significant in the development of these tumors.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Neoplasias Cutâneas
/
Infecções Tumorais por Vírus
/
Genes p53
/
Transplante de Rim
/
Infecções por Papillomavirus
/
Mutação
Limite:
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Reino Unido