Binding of D-galactose-terminated ligands to rabbit asialoglycoprotein receptor.
Carbohydr Res
; 254: 257-68, 1994 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-8180988
The binding affinities of a series of D-galactose-terminated glycerol glycosides and oligosaccharides for the asialoglycoprotein receptor isolated from rabbit liver were determined in vitro using a radioreceptor-inhibition assay with 125I-asialoorosomucoid. The relative affinities of the synthetic ligands increased with the number of exposed D-galactose termini. Of the compounds examined, 1,2,3-tri-O-beta-lactosylglycerol associated with the greatest affinity (estimated Kd = 7.97 x 10(-5) M). Examination of the affinities of the synthetic series indicated that both the number and propinquity of the D-galactose termini influenced the strength of the binding interactions.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Receptores de Superfície Celular
/
Galactose
/
Ligantes
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Carbohydr Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Canadá
País de publicação:
Holanda